North Korea will be a key topic at Friday's summit between Presidents Moon and Biden.
White House Press Secretary Jen Psaki said Thursday that the regime is expected to be high on the agenda.
The summit comes as the Biden administration has completed its policy review on North Korea.
Psaki added that climate change, economic ties and China are also on the table.
However, she ruled out the possibility of President Biden asking his South Korean counterpart to join the U.S.-led initiative known as QUAD.
In addition, Psaki said the U.S. welcomes the opportunity to discuss ways to support South Korea's fight against COVID-19.
Seoul wants a vaccine swap deal or a technology transfer with Washington.