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S. Korean research team finds enzyme that interferes with recovery from brain damage Updated: 2021-05-17 08:46:09 KST

Stroke patients who survive the bursting or clogging of an artery often suffer devastating long-term damage to their health.
As brain cells die, patients can lose their language and motor skills.
Currently, there is no definite treatment, leaving rehabilitation as the only option for patients to regain some of those functions.


It's not that the functions are regained from brain neurons being repaired.
Adjacent neurons partially replace the function or a remaining stem cell is renewed into a neuron to take on the function.

A joint team of researchers at the Korea Institute of Science and Technology and Kyungpook National University found that there is a special protein that helps damaged brain cells recover.
The 'Hevin-Calcyon' protein bond allows surrounding neurons to make more connections.
However, the team further confirmed that if the brain is damaged and inflamed, a special enzyme is secreted that blocks the making of proteins that help with recovery.


We found that there is a protease called 'mmp3' which increases significantly in reaction to inflammation, and animal testing showed that an excess of the 'mmp3' protease significantly delayed neuron repair.

The next step for the research team is to find a way to suppress the enzyme that interferes with the brain's recovery.
Lee Eunjin, Arirang News
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